Remodeling DNA by phases
نویسندگان
چکیده
منابع مشابه
Chromatin remodeling by DNA bending, not twisting.
Single-stranded regions (gaps) in nucleosomal DNA interfere with action of the RSC chromatin-remodeling complex, monitored by exposure of restriction endonuclease cutting sites. Single-strand breaks (nicks) in the DNA, by contrast, have no effect. Gaps on one side of the cutting site are inhibitory, but gaps on the other side are not. A gap >100 bp from the cutting site is as effective as a gap...
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Recent experiments on aligned DNA show hexatic order with no sign of macroscopic chirality. I make the analogy between smectic liquid crystals and chiral hexatics and show how the absence of chirality cannot occur in a thermodynamic phase of chiral molecules. In addition, I discuss the microscopic origin of chiral mesophases in liquid crystals and show that, within the context of central forces...
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Chromatin structures have to be precisely duplicated during DNA replication to maintain tissue-specific gene expression patterns and specialized domains, such as the centromeres. Chromatin remodeling factors are key components involved in this process and include histone chaperones, histone modifying enzymes and ATP-dependent chromatin remodeling complexes. Several of these factors interact dir...
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ژورنال
عنوان ژورنال: Science
سال: 2016
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.352.6291.1289-e